Distribution of the glutamate transporters GLT-1 (SLC1A2) and GLAST (SLC1A3) in peripheral organs

The glutamate transporters GLT-1 and GLAST are widely expressed in astrocytes in the brain where they fulfill important functions during glutamatergic neurotransmission. The present study examines their distribution in peripheral organs using in situ hybridization (ISH) and immunocytochemistry. GLAST was found to be more widely distributed than GLT-1. GLAST was expressed primarily in epithelial cells, cells of the macrophage-lineage, lymphocytes, fat cells, interstitial cells, and salivary gland acini. GLT-1 was primarily expressed in glandular tissue, including mammary gland, lacrimal gland, and ducts and acini in salivary glands, but also by perivenous hepatocytes and follicular dendritic cells in spleen and lymph nodes. The findings demonstrate that, although expressed by the same cells in the brain, these two glutamate transporters have different distribution patterns in peripheral tissues and that they fulfill glutamate transport functions apart from glutamatergic neurotransmission in these area

Organizational Water Footprint to Support Decision Making: a Case Study for a German Technological Solutions Provider for the Plumbing Industry

With water scarcity representing an increasing threat to humans, the environment and the economy, companies are interested in exploring how their operations and supply chains affect water resources globally. To allow for systematically compiling the water footprint at the company level, the organizational water footprint method based on ISO 14046 and ISO/TS 14072 was developed. This paper presents the first complete organizational water scarcity footprint case study carried out for Neoperl GmbH, a German company that offers innovative solutions regarding drinking water for the plumbing industry. The cradle-to-gate assessment for one year includes, besides facility-based production activities, purchased materials, electricity and fuels, and supporting activities, such as company vehicles and infrastructure. Neoperl’s total freshwater consumption amounts to approximately 110,000 m3, 96% thereof being attributable to the supply chain, with freshwater consumption through purchased metals playing the predominant role. Metals (mainly stainless steel and brass) are major hotspots, also when considering the water scarcity-related local impacts resulting from freshwater consumption, which mainly affect China and Chile. These results can be used to improve the company’s supply chain water use in cooperation with internal and external stakeholders by means of, e.g., sustainable purchase strategies or eco-design options to substitute water intensive materials.BMBF, 02WGR1429, GROW - Verbundprojekt WELLE: Wasserfußabdruck für Unternehmen - Lokale Maßnahmen in Globalen WertschöpfungskettenDFG, 414044773, Open Access Publizieren 2019 - 2020 / Technische Universität Berli

Collective vs. individual behaviour for sums of i.i.d. random variables: appearance of the one-big-jump phenomenon

This article studies large and local large deviations for sums of i.i.d. real-valued random variables in the domain of attraction of an $\alpha$-stable law, $\alpha\in (0,2]$, with emphasis on the case $\alpha=2$. There are two different scenarios: either the deviation is realised via a collective behaviour with all summands contributing to the deviation (a Gaussian scenario), or a single summand is atypically large and contributes to the deviation (a one-big-jump scenario). Such results are known when $\alpha \in (0,2)$ (large deviations always follow a one big-jump scenario) or when the random variables admit a moment of order $2+\delta$ for some $\delta>0$. We extend these results, including in particular the case where the right tail is regularly varying with index $-2$ (treating cases with infinite variance in the domain of attraction of the normal law). We identify the threshold for the transition between the Gaussian and the one-big-jump regimes; it is slightly larger when considering local large deviations compared to integral large deviations. Additionally, we complement our results by describing the behaviour of the sum and of the largest summand conditionally on a (local) large deviation, for any $\alpha\in (0,2]$, both in the Gaussian and in the one-big-jump regimes. As an application, we show how our results can be used in the study of condensation phenomenon in the zero-range process at the critical density, extending the range of parameters previously considered in the literature.Comment: 54 page

Pre-Vocational Education in Seven European Countries: a comparison of curricular embedding and implementation in schools

This paper presents a comparative research project on pre-vocational education in lower secondary schools in seven European countries. The primary aim of the study was to better understand how the formal pre-vocational education curriculum is interpreted and shaped by individual teachers. The countries covered are Austria, Germany, Hungary, Latvia, Poland, Portugal and Scotland. Two research methods have been used. First, a content analysis of the relevant curricula was carried out, focussing on how, and to what extent, pre-vocational education competencies are embedded in the official curriculum in the seven countries covered by the study. Second, 75 teachers took part in qualitative expert interviews about their implementation of the relevant curriculum. This research builds upon previous studies in education and employment and in particular, on a theoretical framework that explores the differences between the ‘prescribed' curriculum and the ‘enacted' curriculum. This study will argue that, although it is possible to identify a distinct pre-vocational curriculum within each region in the seven countries, this curriculum is, in practice, taught very differently within the schools and that the differences in curriculum implementation can be explained, amongst other factors, by the availability of resources and the initial and further training of teachers